Evaluation of The Renal Function in The Intrauterine Growth Restricted Rats and The Effect of Maternal Glucocorticoids

The purpose of the study was to determine effect maternal glucocorticoids on experimental growth retardedrats and undernutrition in different gestation periods for function kidney. This studyhad two sections. In first section, 5 groups were formed. 10g/d diet given 1st, 2nd, 3rd trimesterand throughout pregnancy period. control group fed a normal diet. second 3 groupsformed all rats take 10 g/d To endogenousglucocorticoids treated with metyrapone, metyrapone+dexamethasone theplacebo injected saline until 14 days pregnancy. offsprings body kidney weights detected inthe 0, 20th weeks age. Renal extraction functions blood pressures from tail 20thweek Urinary excretion glomerular filtration rate low that had dietary restriction thelast trimester. rates found be duringthe whole Blood pressure values lower duringtheir compared group. Kidney similar phase. Itwas observed renal preserved receiving metyrapone treatment, butthere no statistically significant difference between results. Low normalized withmetyrapone treatment. sizes at week which treatment werefound smaller than those physiological solution. Food destroys functionsbut effects high adulthood. Glucocortiod exposure may reduce renaldevelopment.